Vemurafenib

The Basics

What is Vemurafenib?

Can treat melanoma.

Brand names for Vemurafenib

Zelboraf

How Vemurafenib is classified

Antineoplastic Agents, Enzyme Inhibitors, Protein Kinase Inhibitors, Signal Transduction Inhibitors, Tyrosine Kinase Inhibitors

Vemurafenib During Pregnancy

Vemurafenib pregnancy category

Category N/ANote that the FDA has deprecated the use of pregnancy categories, so for some medications, this information isn’t available. We still think it’s useful to list historical info, however, given what a common proxy this has been in the past.

What we know about taking Vemurafenib while pregnant

N/A

Taking Vemurafenib While Breastfeeding

What are recommendations for lactation if you're taking Vemurafenib?

No information is available on the clinical use of vemurafenib during breastfeeding. Because vemurafenib is more than 99% bound to plasma proteins, the amount in milk is likely to be low. However, its half-life is 57 hours and it might accumulate in the infant. The manufacturer recommends that breastfeeding be discontinued during vemurafenib therapy and for 2 weeks after the final dose.

Maternal / infant drug levels

No information is available on the clinical use of vemurafenib during breastfeeding. Because vemurafenib is more than 99% bound to plasma proteins, the amount in milk is likely to be low. However, its half-life is 57 hours and it might accumulate in the infant. The manufacturer recommends that breastfeeding be discontinued during vemurafenib therapy and for 2 weeks after the final dose.

Possible effects of Vemurafenib on milk supply

Relevant published information was not found as of the revision date.

Possible alternatives to Vemurafenib

None listed